The Sunset Limited Amtrak train line runs three days a week and connects Los Angeles to New Orleans with service to downtown Tucson. Downtown is also home to the Greyhound Bus station, open 24 hours all year long.
All of the major car rental agencies have fleets at Tucson International Airport. You'll also find a number of rental car agencies throughout the city if looking for a shorter-term or specialty rental during your stay.
Tucson's Sun Link Streetcar will link the University of Arizona to the Mercado neighborhood by way of downtown Tucson and the popular 4th Avenue dining, shopping, and entertainment district, following the main artery of Tucson's Urban Core.